Hong Pan, Ph.D.

Site-Specific Project Co-Investigator, Brigham and Women's Hospital

Hong Pan, Ph.D., serves as the Image Analysis Scientist at Functional Neuroimaging Laboratory (FNL), Brigham and Women’s Hospital, Harvard Medical School. Hong obtained his B.S. and M.S. degrees in Engineering from Shanghai Jiao Tong University in Shanghai, China, and was majored in Biomedical Engineering, including one and a half year curriculum of biology and medicine at then Shanghai Medical University and its affiliated hospitals. His electrical and biomedical engineering research work involved topics ranging from digital instrumentation of microcomputer-controlled I.C.U. monitoring system to nonparametric spectral analysis methods with applications in digital signal detection, de-noising, and EEG signal analysis.


Hong then devoted the next five years to computational neuroscience research at Institute of Biophysics, Chinese Academy of Sciences in Beijing, China, and conducted theoretical studies on nonlinear neurodynamics of central pattern generator in Tritonia escape swimming and network self-organization mechanism of neural development in mammalian visual system.
Hong entered his Ph.D. program at the School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana, in 1993. While continuing his work on neural computation, he ventured into the field of mathematical statistics and machine learning, and studied the design and analysis of modern regression methods, and spent his time of preparing his dissertation on hierarchical Bayesian approach to nonparametric regression models such as neural networks, at the Department of Electrical Engineering, UCLA.
Upon obtaining his Ph.D. degree in 1999, Hong joined the FNL, co-directed by Drs. Silbersweig and Stern, at Cornell University Medical College, and was responsible for developing, designing, implementing, testing, and maintaining new biomedical image processing and statistical analysis methods, algorithms and software packages for multi-modal imaging data acquisition, processing, analysis, and visualization. Particularly, he has introduced and implemented a whole set of advanced univariate and multivariate statistical methods, including multi-level mixed-effects models and multi-way hierarchical clustering methods, to the field of functional neuroimaging research, with HPC implementation in interactive parallel/distributed computing environments.
Research Interests: mathematical statistics, biomedical image processing and analysis, and neural computation and machine learning.

Recent Publications:

Beutel ME, Stark R, Pan H, Silbersweig DA, Dietrich S. Psychotherapeut. Langzeitergebnisse einer Funktionellen-Magnetresonanztomographie-Studie. 2012; 57(3):227-233.

Epstein J, Perez DL, Ervin K, Pan H, Kocsis JH, Butler T, Stern E, Silbersweig DA. Failure to segregate emotional processing from cognitive and sensorimotor processing in major depression. Psychiatry Res. 2011 Sep 30; 193(3):144-50.
Pan H, Epstein J, Silbersweig DA, Stern E. New and emerging imaging techniques for mapping brain circuitry. Brain Res Rev. 2011 Jun 24; 67(1-2):226-51.
Tuescher O, Protopopescu X, Pan H, Cloitre M, Butler T, Goldstein M, Root JC, Engelien A, Furman D, Silverman M, Yang Y, Gorman J, LeDoux J, Silbersweig D, Stern E. Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD. J Anxiety Disord. 2011 Mar; 25(2):251-7.
Beutel ME, Stark R, Pan H, Silbersweig D, Dietrich S. Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: an fMRI study of panic disorder patients. Psychiatry Res. 2010 Nov 30; 184(2):96-104.
Ma Y, Huang C, Dyke JP, Pan H, Alsop D, Feigin A, Eidelberg D. Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI. J Cereb Blood Flow Metab. 2010 Mar; 30(3):505-9.
Root JC, Tuescher O, Cunningham-Bussel A, Pan H, Epstein J, Altemus M, Cloitre M, Goldstein M, Silverman M, Furman D, Ledoux J, McEwen B, Stern E, Silbersweig D. Frontolimbic function and cortisol reactivity in response to emotional stimuli. Neuroreport. 2009 Mar 4; 20(4):429-34.
Duan S, Wan L, Fu WJ, Pan H, Ding Q, Chen C, Han P, Zhu X, Du L, Liu H, Chen Y, Liu X, Yan X, Deng M, Qian M. Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation. Apoptosis. 2009 Feb; 14(2):236-45.
Cunningham-Bussel AC, Root JC, Butler T, Tuescher O, Pan H, Epstein J, Weisholtz DS, Pavony M, Silverman ME, Goldstein MS, Altemus M, Cloitre M, Ledoux J, McEwen B, Stern E, Silbersweig D. Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli. Psychoneuroendocrinology. 2009 Jun; 34(5):694-704.
Veselis RA, Pryor KO, Reinsel RA, Mehta M, Pan H, Johnson R. Low-dose propofol-induced amnesia is not due to a failure of encoding: left inferior prefrontal cortex is still active. Anesthesiology. 2008 Aug; 109(2):213-24.